Viral Inactivation of Human Osteochondral Grafts with Methylene Blue and Light

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Viral Inactivation of Human Osteochondral Grafts with Methylene Blue and Light

OBJECTIVE Cartilage injury is one of the most common disorders of synovial joints. Fresh osteochondral allografts are becoming a standard treatment; however, they are supply constrained with a potential risk of disease transmission. There are no known virucidal processes available for osteochondral allografts and most methods presently available are detrimental to cartilage. Methylene blue ligh...

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The Effect of Methylene Blue in Combination with Red Visible Light on Model Viruses Inactivation and Coagulation Factors in Fresh Frozen Plasma

Background and Aims: Fresh Frozen Plasma (FFP) is one of blood components. The risk of transmission of viruses from blood components regardless selection of blood donors and screening donated blood still remains. There are several methods for viral inactivation. In this study methylene blue (MB) photo inactivation process was used for inactivating viruses. Materials and Methods: In this study M...

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Mechanisms of photodynamic inactivation of herpes simplex viruses: comparison between methylene blue, light plus electricity, and hematoporhyrin plus light.

Herpes simplex virus (HSV) types 1 and 2 have been inactivated in vitro using low concentrations of methylene blue (MB), light (lambda) plus electricity (E), or hematoporphyrin derivative (HPD) plus lambda. Both techniques introduce single strand interruptions into viral DNA, but do not make double strand ruptions into viral DNA, but do not make double strand breaks. MB, lambda plus E-treated v...

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ژورنال

عنوان ژورنال: CARTILAGE

سال: 2013

ISSN: 1947-6035,1947-6043

DOI: 10.1177/1947603513509650